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KMID : 0368820070460030214
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Journal of the Korean Neuropsychiatr Association
2007 Volume.46 No. 3 p.214 ~ p.222
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Naturalistic, Retrospective Study on Clinical Experience of Ziprasidone in 3 University Hospitals
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Lee Seung-Jae
Kang Do-Hyung
Hong Kyung-Sue
Joo Yeon-Ho
Kim Nam-Sick
kwon Jun-Soo
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Abstract
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Objectives: This naturalistic retrospective study investigated the effectiveness of ziprasidone measured by mean improvements of the Clinical Global Impression (CGI-I). Secondary objectives included prescribing patterns, tolerability and safety.
Methods: From May to July 2006, 98 psychiatric patients who have been taking ziprasidone for at least 2 weeks were selected. Their current clinical statuses were assessed by the interview and laboratory tests including electrocardiogram (ECG). Data on DSM-IV diagnoses, dosing, concomitant psychotropic medications, clinical changes, adverse effects, and laboratory findings were collected retrospectively.
Results: Ziprasidone was mostly prescribed for a switch from another antipsychotics for the treatment of schizophrenia. Two main reasons for a switch were unsatisfactory efficacy and poor tolerance, especially weight gain, of the preceding antipsychotic medication. Participants as a whole showed mean 2.7+/-1.0 of the CGI-Improvement. Significant weight reduction after switching to ziprasidone occurred, which was related to the clinical improvement. No significant increase of the QTc interval except one case was observed.
Conclusion: The present study confirmed previous tolerability and safety data of ziprasidone as well as the results of its effectiveness.
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KEYWORD
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Ziprasidone, Efficacy, Side effect, Schizophrenia, Other psychiatric disorder
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